Otenabant hydrochloride
CAS No. 686347-12-6
Otenabant hydrochloride ( CP 945598 Hydrochloride;CP-945598 Hydrochloride;CP945598 Hydrochloride )
Catalog No. M15623 CAS No. 686347-12-6
A potent, and selective CB1 receptor antagonist with Ki of 0.7 nM/0.12 nM in binding and functional assays respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 49 | In Stock |
|
5MG | 67 | In Stock |
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10MG | 111 | In Stock |
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25MG | 227 | In Stock |
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50MG | 419 | In Stock |
|
100MG | 615 | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameOtenabant hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, and selective CB1 receptor antagonist with Ki of 0.7 nM/0.12 nM in binding and functional assays respectively.
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DescriptionA potent, and selective CB1 receptor antagonist with Ki of 0.7 nM/0.12 nM in binding and functional assays respectively; has low affinity (Ki=7600 nM) for human CB2 receptors; reverses cannabinoid agonist mediated responses, reduces food intake, and increases energy expenditure and fat oxidation in rodents.Obesity Phase 3 Discontinued
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SynonymsCP 945598 Hydrochloride;CP-945598 Hydrochloride;CP945598 Hydrochloride
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PathwayGPCR/G Protein
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TargetCannabinoid Receptor
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RecptorhCB1;hCB2;rCB1
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Research AreaMetabolic Disease
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IndicationObesity
Chemical Information
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CAS Number686347-12-6
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Formula Weight546.88
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Molecular FormulaC25H26Cl3N7O
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Purity>98% (HPLC)
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SolubilityDMSO: 1 mg/mL
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SMILESCCNC1(CCN(CC1)C1=NC=NC2=C1NC(N2C1=CC=C(Cl)C=C1)C1=CC=CC=C1Cl)C(N)=O
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Chemical Name4-Piperidinecarboxamide, 1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-(ethylamino)-, hydrochloride (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Fulp A, et al. J Med Chem. 2012 Nov 26;55(22):10022-32.
2. Hadcock JR, et al. Biochem Biophys Res Commun. 2010 Apr 2;394(2):366-71.
3. Aronne LJ, et al. Obesity (Silver Spring). 2011 Jul;19(7):1404-14.
2. Hadcock JR, et al. Biochem Biophys Res Commun. 2010 Apr 2;394(2):366-71.
3. Aronne LJ, et al. Obesity (Silver Spring). 2011 Jul;19(7):1404-14.
molnova catalog
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